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Journal: Journal of Pharmaceutical and Biomedical Analysis Open
Article Title: " Quartz Crystal Microbalance-Based Biosensor for Rapid and Ultrasensitive SARS-CoV-2 Detection"
doi: 10.1016/j.jpbao.2025.100071
Figure Lengend Snippet: Figure 1a: (Left) OpenQCM, scale bar 10mm , (Right)Sequential steps involved in the surface functionalization. (a) Sensor is cleaned with distilled water (DIW) after piranha and sodium hydroxide treatment. (b) Addition of 1 mg/mL solution of thiol- PEG-carboxyl (HS-PEG-COOH, MW 5K). (c) Activation of COOH-PEG-SH and addition of beta-mercaptoethanol to quench 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide (d) Addition of SARS-CoV-2 Nucleocapsid Protein (E8R1L) Mouse monoclonal antibody mAb and incubation for 2 hours at room temperature. (e) Addition of SARS-CoV-2 heat inactivated virus sample to the surface.
Article Snippet: Following functionalization and activation, 20 μL of
Techniques: Activation Assay, Incubation, Virus
Journal: Journal of Pharmaceutical and Biomedical Analysis Open
Article Title: " Quartz Crystal Microbalance-Based Biosensor for Rapid and Ultrasensitive SARS-CoV-2 Detection"
doi: 10.1016/j.jpbao.2025.100071
Figure Lengend Snippet: Figure 2: Digital holographic microscopy images of: (a) bare gold surface, (b) sensor surface after immobilization of SARS-CoV-2 nucleocapsid protein (E8R1L) mouse monoclonal antibody (mAb), (c) sensor surface after the addition of SARS-CoV-2 antigen, and (d) sensor surface after BSA coating. (e) Changes in surface roughness, measured using digital holographic microscopy, at various stages of the chemical immobilization process. The graph illustrates the increase in roughness from the clean sensor to subsequent steps.
Article Snippet: Following functionalization and activation, 20 μL of
Techniques: Digital Holographic Microscopy